M1 Muscarinic Receptors Inhibit L-type Ca2+ Current and M-Current by Divergent Signal Transduction Cascades
نویسندگان
چکیده
منابع مشابه
M1 muscarinic receptors inhibit L-type Ca2+ current and M-current by divergent signal transduction cascades.
Ion channels reside in a sea of phospholipids. During normal fluctuations in membrane potential and periods of modulation, lipids that directly associate with channel proteins influence gating by incompletely understood mechanisms. In one model, M(1)-muscarinic receptors (M(1)Rs) may inhibit both Ca(2+) (L- and N-) and K(+) (M-) currents by losing a putative interaction between channels and pho...
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Liwang Liu,1,2 Rubing Zhao,2 Yan Bai,2 Lee F. Stanish,2 James E. Evans,3 Michael J. Sanderson,2 Joseph V. Bonventre,4 and Ann R. Rittenhouse1,2 1Program in Neuroscience and Departments of 2Physiology and 3Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, and 4Harvard Institute of Medicine, Harvard Medical School and Brigham and ...
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Neuromodulators released during and after a fearful experience promote the consolidation of long-term memory for that experience. Because overconsolidation may contribute to the recurrent and intrusive memories of post-traumatic stress disorder, neuromodulatory receptors provide a potential pharmacological target for prevention. Stimulation of muscarinic receptors promotes memory consolidation ...
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A B S TRACT The relationship between the deplet ion of IP3-releasable intracellular Ca z+ stores and the activation of Ca2+-selective membrane current was determined dur ing the st imulation of M1 muscarinic receptors in N1E-115 neuroblastoma cells. External Ca 2+ is required for refilling Ca 2+ stores and the voltage-independent , receptor-regulated Ca 2+ current represents a significant Ca 2+...
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BACKGROUND Apamin is commonly used as a small-conductance Ca2+-activated K+ (SK) current inhibitor. However, the specificity of apamin in cardiac tissues remains unclear. OBJECTIVE To test the hypothesis that apamin does not inhibit any major cardiac ion currents. METHODS We studied human embryonic kidney (HEK) 293 cells that expressed human voltage-gated Na+, K+ and Ca2+ currents and isola...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2006
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.2102-06.2006